Palestine was the name used most commonly, consistently and continuously for over 1200 years throughout classical and Late Antiquity, from the highlight of classical Athenian civilisation in 500 BC until the end of the Byzantine period and the occupation of Palestine by the Muslim armies in 637‒638 AD.

To substitute the vague and imprecise term Cana’an for the real historical and official toponym Palaestina used during a classical period lasting over a millennium would be tantamount to the elimination of the history of this region and would create major obstacles to an understanding of Classical and Late Antiquity. The substitution of the term Cana’an (known only for a limited period during the Late Bronze Age) for Palaestina would also eliminate the possibility of any real historical knowledge of one of the most important periods in the ancient history of the region, namely early Christianity and Byzantine Palestine. Greek-speaking Byzantine Christianity in Palestine began in the reign of the Roman Emperor Constantine the Great (306–337 AD) and lasted until the beginning of Muslim rule in Palestine in 637‒638 AD.