《古兰经》没有详细记载以撒的生平,但可靠的经注学者提到,当亚伯拉罕感到自己的生命即将走到尽头时,他希望看到以撒成家。他不希望以撒娶迦南人为妻,因为他们是异教徒,于是他派遣一名可靠的仆人前往伊拉克的哈兰,为以撒挑选新娘。仆人最终选中了利百加,她是Bethuel的女儿、Nahor之子(也就是亚伯拉罕的兄弟)之女。以撒与她成婚,她生下了一对双胞胎,以扫(Al Eis)和雅各(Yaqub)。

The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).

当这两兄弟长大成人后，彼此之间产生了怨恨。以扫不满雅各受到父亲的偏爱，也不满雅各被安拉选为先知。这种怨恨变得十分严重，以至于以扫威胁要杀死自己的兄弟。雅各担心自己的性命，便逃离了那个国家。

Ill feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.

据有经人所说,以撒四十岁时娶了比土利之女利百加,那时其父尚在世。他们说利百加不能生育,于是以撒向安拉祈祷,之后利百加便怀孕了。她生下一对双胞胎男孩。第一个名叫以扫,阿拉伯人称他为阿伊斯,他是罗马人(Rum)的始祖。第二个名叫雅各,意为以色列,即以色列人之族的成员。

The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).

雅各来到他的父亲以撒那里，与他一同定居在希伯伦村。希伯伦位于迦南地，亚伯拉罕曾经在那里居住。之后，以撒病倒了，在他一百八十岁时去世。他的儿子以扫和雅各把他与他的父亲亚伯拉罕（Al Khalil）一同葬在他曾经购买的一个洞穴中。据说，亚伯拉罕去世时享年一百七十五岁。

Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.