Al-Qur'ani ba ya ba da cikakken bayani game da rayuwar Ishaƙ (a.s), amma malaman tafsirin Alƙur'ani masu inganci sun ambata cewa a lokacin da Ibrahim ya ji cewa rayuwarsa tana gab da ƙarewa, sai ya so ganin Ishaƙ ya yi aure. Ba ya so Ishaƙ ya auri ɗaya daga cikin mutanen Kan'ana, waɗanda mushrikai ne, sai ya aika wani bawansa amintacce zuwa Haran a ƙasar Iraƙi domin ya zaɓa wa Ishaƙ amarya. Zaɓin bawan ya faɗa kan Rifkatu 'yar Bethuel, ɗan Nahor (wanda shi ɗan'uwan Ibrahim ne). Ishaƙ ya aure ta, sai ta haifi tagwaye, Isuwa (Al Eis) da Yaƙub (Yaqub).

The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).

Sa'ad da 'yan'uwan biyu suka girma zuwa maza, ƙiyayya ta shiga tsakaninsu. Isuwa ya ƙi cewa Yakubu yana samun fifiko daga wurin mahaifinsu, da kuma daga wurin Allah ta hanyar annabci. Wannan ƙiyayya ta yi tsanani har Isuwa ya yi barazanar kashe ɗan'uwansa. Yakubu, yana tsoron rayuwarsa, ya gudu daga ƙasar.

Ill feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.

Mutanen Littafi sun ce cewa lokacin da Ishaƙu ya kai shekara arba'in, ya auri Rebekah 'yar Bethuel, a lokacin da mahaifinsa yana raye. Sun ce ita bakarariya ce, don haka Ishaƙu ya yi addu'a ga Allah, sai ta samu juna biyu. Ta haifi 'yan biyu maza. Na farko an sanya masa suna Esau, wanda Larabawa suka kira Al-Eis. Shi ne ya zama uban Rum. Na biyu an sanya masa suna Yaƙub, wanda ma'anarsa Isra'ila, (wanda ke cikin mutanen Isra'ila).

The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).

Yakubu ya zo wurin mahaifinsa Ishaku, ya zauna tare da shi a garin Hebron wanda yake cikin ƙasar Kan'ana inda Ibrahim ya taɓa zama. Sai Ishaku ya yi rashin lafiya ya mutu yana da shekara ɗari da tamanin. 'Ya'yansa Isuwa da Yakubu suka binne shi tare da mahaifinsa Ibrahim Al Khalil a cikin kogon da ya saya. An ce Ibrahim ya mutu yana da shekara ɗari da saba'in da biyar.

Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.