Al-Quran tidak memberikan butiran tentang kehidupan Ishak (pbuh), tetapi para pentafsir Al-Quran yang boleh dipercayai menyebut bahawa apabila Ibrahim merasakan hayatnya hampir berakhir, beliau ingin melihat Ishak berkahwin. Beliau tidak mahu Ishak berkahwin dengan salah seorang daripada kaum Kan'an, yang menyembah berhala, lalu beliau menghantar seorang hamba yang amanah ke Haran di Iraq untuk memilih seorang isteri bagi Ishak. Pilihan hamba itu jatuh kepada Rebekah binti Bethuel bin Nahor (yang merupakan saudara Ibrahim). Ishak berkahwin dengannya, dan beliau melahirkan dua orang anak kembar, Esau (Al Eis) dan Yaakub (Yaqub).

The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).

Perasaan tidak senang mula berkembang antara kedua-dua beradik itu apabila mereka membesar menjadi lelaki dewasa. Esau tidak menyukai hakikat bahawa Yaakub lebih disayangi oleh ayah mereka dan dikurniakan kenabian oleh Allah. Perasaan tidak senang ini menjadi begitu serius sehingga Esau mengugut untuk membunuh adiknya. Kerana takut akan keselamatan nyawanya, Yaakub melarikan diri dari negeri itu.

Ill feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.

Ahli Kitab berkata bahawa apabila Ishak berumur empat puluh tahun, beliau berkahwin dengan Rebekah Binti Bethuel, semasa ayahnya masih hidup. Mereka berkata bahawa isterinya mandul, lalu Ishak berdoa kepada Allah dan kemudian isterinya mengandung. Dia melahirkan anak kembar lelaki. Yang pertama dinamakan Esau, yang disebut oleh orang Arab sebagai Al-Eis. Dia menjadi bapa kepada bangsa Rum. Yang kedua dinamakan Jacob, yang bermaksud Israel (tergolong dalam bangsa Israel).

The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).

Yaakub datang kepada ayahnya Ishak dan menetap bersamanya di kampung Hebron yang terletak di tanah Kan'an, tempat Ibrahim pernah tinggal. Kemudian Ishak jatuh sakit dan meninggal dunia pada usia seratus lapan puluh tahun. Anak-anaknya, Esau dan Yaakub, mengebumikannya bersama ayahnya Ibrahim Al Khalil di dalam sebuah gua yang telah dibelinya. Dikatakan bahawa Ibrahim meninggal dunia pada usia seratus tujuh puluh lima tahun.

Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.