Al-Qur'an tidak memberikan rincian tentang kehidupan Ishak (pbuh), namun para ahli tafsir Al-Qur'an yang terpercaya menyebutkan bahwa ketika Ibrahim merasa ajalnya sudah dekat, ia ingin melihat Ishak menikah. Ia tidak menginginkan Ishak menikah dengan salah satu dari bangsa Kan'an, yang merupakan kaum penyembah berhala, maka ia mengirim seorang hamba yang terpercaya ke Haran di Irak untuk memilih seorang istri bagi Ishak. Pilihan hamba tersebut jatuh kepada Ribka binti Betuel bin Nahor (yang merupakan saudara Ibrahim). Ishak menikah dengannya, dan ia melahirkan sepasang anak kembar, Esau (Al Eis) dan Yakub (Yaqub).

The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).

Perasaan tidak enak berkembang di antara kedua saudara itu ketika mereka beranjak dewasa. Esau tidak suka dengan kenyataan bahwa Yakub lebih disayang oleh ayahnya dan oleh Allah dengan kenabian. Perasaan tidak enak ini menjadi begitu serius sehingga Esau mengancam akan membunuh saudaranya. Karena takut akan keselamatan jiwanya, Yakub melarikan diri dari negeri itu.

Ill feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.

Ahli Kitab mengatakan bahwa ketika Ishaq berusia empat puluh tahun, ia menikahi Rebekah binti Bethuel, selagi ayahnya masih hidup. Mereka mengatakan bahwa Rebekah itu mandul, maka Ishaq berdoa kepada Allah, lalu Rebekah pun hamil. Ia melahirkan anak kembar laki-laki. Yang pertama dinamakan Esau, yang oleh orang-orang Arab disebut Al-Eis. Ia menjadi bapak bangsa Rum. Yang kedua dinamakan Yakub, yang artinya Israel, (milik bangsa Israel).

The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).

Yakub datang kepada ayahnya, Ishak, dan menetap bersamanya di desa Hebron yang terletak di tanah Kanaan, tempat Ibrahim pernah tinggal. Kemudian Ishak jatuh sakit dan wafat pada usia seratus delapan puluh tahun. Anak-anaknya, Esau dan Yakub, memakamkannya bersama ayahnya, Ibrahim Al Khalil, di sebuah gua yang telah ia beli. Dikatakan bahwa Ibrahim wafat pada usia seratus tujuh puluh lima tahun.

Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.