El Corán no ofrece detalles de la vida de Isaac (la paz sea con él), pero comentaristas confiables del Corán mencionaron que cuando Abraham sintió que su vida llegaba a su fin, deseó ver casado a Isaac. No quería que Isaac se casara con una de las mujeres cananeas, que eran paganas, así que envió a Harán, en Iraq, a un siervo de confianza para que escogiera una esposa para Isaac. La elección del siervo recayó en Rebeca, hija de Betuel, hijo de Najor (que era hermano de Abraham). Isaac se casó con ella, y ella dio a luz a unos mellizos, Esaú (Al Eis) y Jacob (Yaqub).

The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).

Surgieron malos sentimientos entre los dos hermanos cuando llegaron a la edad adulta. Esaú no veía con buenos ojos que Jacob fuera preferido por su padre y por Allah con la profecía. Este resentimiento llegó a ser tan grave que Esaú amenazó con matar a su hermano. Temiendo por su vida, Jacob huyó del país.

Ill feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.

Los Pueblos del Libro dijeron que, cuando Isaac tenía cuarenta años, se casó con Rebeca, hija de Betuel, durante la vida de su padre. Dijeron que ella era estéril, por lo que Isaac oró a Allah y entonces ella quedó embarazada. Dio a luz a mellizos varones. El primero se llamaba Esaú, a quien los árabes llamaban Al-Eis. Llegó a ser el padre de los Rum. El segundo se llamaba Jacob, que significa Israel (perteneciente al pueblo de Israel).

The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).

Jacob llegó junto a su padre Isaac y se estableció con él en la aldea de Hebrón, que se encuentra en la tierra de Canaán, donde había vivido Abraham. Luego Isaac enfermó y murió a la edad de ciento ochenta años. Sus hijos Esaú y Jacob lo enterraron junto a su padre Abraham, el Amigo de Dios, en una cueva que este había comprado. Se dice que Abraham murió a la edad de ciento setenta y cinco años.

Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.