Ketika Abu Thalib, paman Rasulullah ﷺ, dan istri Rasulullah ﷺ, Khadijah (semoga Allah meridainya), wafat dalam tahun yang sama, musibah yang menimpa Rasulullah ﷺ menjadi semakin besar karena kepergian keduanya. Kaum Quraisy telah sampai pada tahap menyakiti Rasulullah ﷺ, sesuatu yang tidak pernah mereka lakukan sebelum wafatnya paman beliau, hingga mereka melemparkan debu ke atas kepala beliau. Rasulullah ﷺ pernah bersabda: "Kaum Quraisy tidak pernah melakukan sesuatu yang lebih menyakitkan bagiku, kecuali setelah Abu Thalib wafat." [Sirah Ibnu Hisyam]. Setelah Abu Thalib wafat, Rasulullah ﷺ pergi ke Thaif untuk mencari dukungan dan perlindungan dari penduduknya. Beliau mendatangi sekelompok orang dari Bani Tsaqif, yang pada saat itu merupakan para pemimpin dan pembesar Tsaqif. Beliau berbicara kepada mereka tentang dukungan terhadap Islam dan berdiri bersama beliau melawan siapa pun dari kaumnya yang menentang beliau. Mereka menolak tawaran itu dan menyebarkan kabar kedatangan beliau kepada kaumnya, meskipun beliau telah meminta mereka untuk merahasiakan kunjungan ini. Beliau tidak dapat masuk ke Makkah, kecuali dengan jaminan perlindungan.

When Abu Talib, the uncle of the Messenger 􀁕, and the Messenger’s wife Khadijah (may Allah be pleased with her) both died in the same year, the misfortune for the Messenger 􀁕 became greater due to their death. The Quraysh had reached the point of inflicting harm on the Messenger 􀁕, which they never did before the death of his uncle, to the point they threw dust on his head. The Messenger 􀁕 used to say; “Quraysh did not do anything more hateful to me, except after Abu Talib died.” [Sirah of Ibn Hisham]. When Abu Talib died, the Messenger 􀁕 went to Taa’if seeking the support and protection of its people. He went to a group of people from the Banu Thaqeef, who at that time, were the leaders and chiefs of the Thaqeef. He spoke to them about supporting Islam and standing beside him, against anyone who opposed him from his people. They rejected his offer and transmitted the news of his arrival to his people, even though he asked them to keep this visit secret. He was not able to enter Makkah, except under sanctuary.